Chou S, Lurain N S, Weinberg A, Cai G Y, Sharma P L, Crumpacker C S
VA Medical Center, Portland, Oregon 97201, USA.
Antimicrob Agents Chemother. 1999 Jun;43(6):1500-2. doi: 10.1128/AAC.43.6.1500.
The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1, 237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.
测定了40株对更昔洛韦和膦甲酸钠敏感的独立临床巨细胞病毒分离株的聚合酶（pol）编码序列。序列比对显示，菌株间同源性>98%，在1237个密码子中只有4%存在氨基酸变异。几乎所有变异都发生在已鉴定出耐药突变的保守功能域之外。
Zotero 插件