阿司匹林对人体血小板计数及体积的影响。
Influence of aspirin on platelet count and volume in humans.
作者信息
Erhart S, Beer J H, Reinhart W H
机构信息
Internal Medicine, Kantonsspital, Chur, Switzerland.
出版信息
Acta Haematol. 1999;101(3):140-4. doi: 10.1159/000040940.
Platelet volume and total platelet mass are parameters of platelet activity and have become a prognostic factor in coronary heart disease. We have studied the influence of aspirin on platelet count, volume and total platelet mass in vitro and in a randomized double-blind, placebo-controlled study in 20 healthy young male volunteers in vivo. Aspirin had no influence in vitro on either platelet count, volume or mass. Repeated blood sampling during a 7-day treatment with 250 mg aspirin daily showed an increased platelet count (7.3% on day 1, 3.0% on day 2, 6.8% on day 4 and 9.3% on day 7; p < 0.01) and total platelet mass (7.2, 5.0, 8.6 and 11.5% on days 1, 2, 4 and 7, respectively, p < 0.01). Aspirin treatment without repeated blood withdrawal had no effect. These data indicate that aspirin may affect the circulating platelet mass under certain conditions.
血小板体积和血小板总质量是血小板活性的参数，已成为冠心病的一个预后因素。我们在体外以及在一项针对20名健康年轻男性志愿者的随机双盲、安慰剂对照的体内研究中，研究了阿司匹林对血小板计数、体积和血小板总质量的影响。阿司匹林在体外对血小板计数、体积或质量均无影响。在每天服用250毫克阿司匹林进行为期7天的治疗期间，重复采血显示血小板计数增加（第1天增加7.3%，第2天增加3.0%，第4天增加6.8%，第7天增加9.3%；p<0.01）以及血小板总质量增加（第1、2、4和7天分别增加7.2%、5.0%、8.6%和11.5%，p<0.01）。未重复采血的阿司匹林治疗没有效果。这些数据表明，阿司匹林在某些情况下可能会影响循环中的血小板质量。
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