Özkan Buğra, Örsçelik Özcan, Yıldırım Yaroğlu Hatice, Balcı Şenay, Özcan Mert Koray, Çelik Ahmet, Özcan Ismail Türkay
Department of Cardiology, Faculty of Medicine, Mersin University; Mersin-Turkey.
Department of Biochemistry, Faculty of Medicine, Mersin University; Mersin-Turkey.
Anatol J Cardiol. 2019 Nov;22(5):250-255. doi: 10.14744/AnatolJCardiol.2019.90349.
Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE.
Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a control group of 52 patients.
Serum adropin level was found to be significantly lower in the isolated CAE group compared to the control group (1019.57 pg/mL and 1151.10 pg/mL, respectively, p=0.010). The isolated CAE group also exhibited a significantly higher mean platelet volume than that in the control group (10.75 fL and 10.17 fL, respectively, p=0.011).
Our results show that there is an association between low serum adropin level and isolated CAE.
一个或多个冠状动脉节段扩张至直径至少为相邻正常节段直径的1.5倍被称为冠状动脉扩张（CAE）。内脂素是一种参与内皮功能的蛋白质，已显示对心脏功能调节具有保护作用。动脉粥样硬化和内皮功能障碍在CAE的发展中起重要作用。本研究的目的是探讨血清内脂素水平与孤立性CAE之间的关联。
对2017年8月至2018年7月期间接受冠状动脉造影（CAG）的稳定型心绞痛患者进行前瞻性评估。共有92名受试者纳入研究——40名18岁以上根据CAG结果诊断为孤立性CAE的患者以及52名患者组成的对照组。
发现孤立性CAE组的血清内脂素水平显著低于对照组（分别为1019.57 pg/mL和1151.10 pg/mL，p = 0.010）。孤立性CAE组的平均血小板体积也显著高于对照组（分别为10.75 fL和10.17 fL，p = 0.011）。
我们的结果表明血清内脂素水平低与孤立性CAE之间存在关联。
