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人体受试者中食物来源或补充剂中叶醌生物利用度的比较。

Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.

作者信息

Garber A K, Binkley N C, Krueger D C, Suttie J W

机构信息

Department of Nutritional Sciences, Institute on Aging, and Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

出版信息

J Nutr. 1999 Jun;129(6):1201-3. doi: 10.1093/jn/129.6.1201.

DOI:10.1093/jn/129.6.1201
PMID:10356087
Abstract

Phylloquinone (K) absorption was assessed in 22- to 30-y-old human subjects consuming a standard test meal [402 kcal (1682 kJ), 27% energy from fat]. The absorption of phylloquinone, measured over a 9-h period as the area under the curve (AUC), was higher (P < 0.01) after the consumption of a 500- microgram phylloquinone tablet [27.55 +/- 10.08 nmol/(L. h), n = 8] than after the ingestion of 495 microgram phylloquinone as 150 g of raw spinach [4.79 +/- 1.11 nmol/(L. h), n = 3]. Less phylloquinone (P < 0.05) was absorbed from 50 g of spinach (AUC = 2.49 +/- 1.11 nmol/(L. h) than from 150 g of spinach. Absorption of phylloquinone from fresh spinach (165 microgram K), fresh broccoli (184 microgram K) and fresh romaine lettuce (179 microgram K) did not differ. There was no difference in phylloquinone absorption from fresh or cooked broccoli or from fresh romaine lettuce consumed with a meal containing 30 or 45% energy as fat.

摘要

在22至30岁的人类受试者中评估了叶绿醌(K)的吸收情况,这些受试者食用了标准测试餐[402千卡(1682千焦),27%的能量来自脂肪]。以曲线下面积(AUC)衡量的叶绿醌吸收量,在服用500微克叶绿醌片后[27.55±10.08纳摩尔/(升·小时),n = 8]高于摄入495微克叶绿醌(以150克生菠菜形式摄入)后[4.79±1.11纳摩尔/(升·小时),n = 3](P < 0.01)。从50克菠菜中吸收的叶绿醌较少(P < 0.05)(AUC = 2.49±1.11纳摩尔/(升·小时)),低于从150克菠菜中吸收的量。从新鲜菠菜(165微克K)、新鲜西兰花(184微克K)和新鲜长叶生菜(179微克K)中吸收的叶绿醌没有差异。从新鲜或煮熟的西兰花中,以及从与含30%或45%能量为脂肪的餐食一起食用的新鲜长叶生菜中吸收的叶绿醌没有差异。

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