Ancoli-Israel S, Martin J, Jones D W, Caligiuri M, Patterson T, Harris M J, Jeste D V
Department of Psychiatry, University of California, San Diego, USA.
Biol Psychiatry. 1999 Jun 1;45(11):1426-32. doi: 10.1016/s0006-3223(98)00166-8.
Since the prevalence of both sleep-disordered breathing (SDB) and periodic limb movements in sleep (PLMS) increase with age, we explored whether older schizophrenia patients would have a high incidence of SDB and PLMS. Correlations between sleep and clinical variables were also examined.
Fifty-two patients (mean age = 59.6 years, SD = 8.9) had their sleep/wake, respiration, and leg movements recorded using a modified Medilog/Respitrace portable recording system plus oximetry. A battery of clinical, psychosocial, and motor disturbance variables were collected by research center staff.
Forty-eight percent of these patients had at least 10 respiratory events per hour of sleep. These patients reported more symptoms of daytime sleepiness than patients with fewer than 10 events per hour. The relatively high prevalence of SDB in this group may contribute to overall sleep disturbances, and does not appear to be a result of high body mass index. Only 14% of the patients had at least five limb movements per hour of sleep, suggesting the prevalence of PLMS is much lower than expected in this age group. The number of leg jerks was inversely related to symptoms of tardive dyskinesia.
The disturbance of sleep in these patients may be due, in part, to SDB, but is unlikely due to PLMS.
由于睡眠呼吸障碍（SDB）和睡眠期周期性肢体运动（PLMS）的患病率均随年龄增长而增加，我们探讨了老年精神分裂症患者SDB和PLMS的发生率是否会更高。还研究了睡眠与临床变量之间的相关性。
52例患者（平均年龄=59.6岁，标准差=8.9）使用改良的Medilog/Respitrace便携式记录系统加血氧饱和度测定法记录其睡眠/觉醒、呼吸和腿部运动情况。研究中心工作人员收集了一系列临床、心理社会和运动障碍变量。
这些患者中有48%每小时睡眠中至少有10次呼吸事件。与每小时呼吸事件少于10次的患者相比，这些患者报告的日间嗜睡症状更多。该组中SDB的相对高患病率可能导致整体睡眠障碍，且似乎不是高体重指数的结果。只有14%的患者每小时睡眠中至少有5次肢体运动，这表明PLMS在该年龄组中的患病率远低于预期。腿部抽搐次数与迟发性运动障碍症状呈负相关。
这些患者的睡眠障碍可能部分归因于SDB，但不太可能归因于PLMS。
