Youngstedt S D, Kripke D F, Klauber M R, Sepulveda R S, Mason W J
Department of Psychiatry, University of California, San Diego, USA.
J Gerontol A Biol Sci Med Sci. 1998 Sep;53(5):M391-4. doi: 10.1093/gerona/53a.5.m391.
Periodic limb movements in sleep (PLMS) are an increasingly pervasive disturbance for aging adults. The aims of this experiment were: (a) to describe the index of periodic limb movements in sleep (myoclonus index [MI] in elderly subjects with complaints of poor sleep or depression (N = 22; 68 +/- 5.5 SD years); and (b) to correlate MI with sleep history, depression scores, and objective and subjective indices of sleep.
Sleep and leg movements were assessed for 5 consecutive nights. Between-subjects, nonparametric correlations were examined between mean MI and sleep history, depression scores, and objective and subjective sleep characteristics. Associations among within-subject night-to-night variabilities of MI, objective, and subjective variables were examined with repeated measures ANCOVA, entering MI as a covariate.
A remarkably high level of MI was found (median 25.8 events per hour; 86% of subjects > 5). Nevertheless, no associations were found between MI and sleep disturbance measures.
These results extend previous reports that PLMS are remarkably persuasive in elderly volunteers and support other reports questioning whether there is a distinct PLMS syndrome.
睡眠期周期性肢体运动（PLMS）对老年人来说是一种日益普遍的干扰。本实验的目的是：（a）描述睡眠期周期性肢体运动指数（患有睡眠不佳或抑郁主诉的老年受试者的肌阵挛指数[MI]；N = 22；年龄68±5.5标准差岁）；以及（b）将MI与睡眠史、抑郁评分以及睡眠的客观和主观指标相关联。
连续5晚评估睡眠和腿部运动。在受试者之间，检查平均MI与睡眠史、抑郁评分以及客观和主观睡眠特征之间的非参数相关性。以MI作为协变量，采用重复测量协方差分析检查MI、客观和主观变量在受试者内每晚变化之间的关联。
发现MI水平非常高（中位数为每小时25.8次事件；86%的受试者>5）。然而，未发现MI与睡眠干扰指标之间存在关联。
这些结果扩展了先前的报告，即PLMS在老年志愿者中非常有说服力，并支持其他质疑是否存在独特PLMS综合征的报告。
