脑脊液中5-羟吲哚乙酸（5-HIAA）与抑郁症患者的神经质相关。
CSF 5-HIAA correlates with neuroticism in depressed patients.
作者信息
Roy A
机构信息
Psychiatry Service, Department of Veterans Affairs, New Jersey Healthcare System, East Orange 07019, USA.
出版信息
J Affect Disord. 1999 Jan-Mar;52(1-3):247-9. doi: 10.1016/s0165-0327(98)00073-1.
BACKGROUND
To examine for relationships between neurotransmitters and personality.
METHOD
27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ).
RESULT
CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores.
CONCLUSION
Central serotonin may play a role in neuroticism, a personality dimension predisposing to depression.
LIMITATION
The positive correlation may partly reflect collinear relationships between both variables and anxiety/depression.
背景
研究神经递质与人格之间的关系。
方法
对27名抑郁症患者测量脑脊液（CSF）单胺代谢产物，并完成艾森克人格问卷（EPQ）。
结果
血清素代谢产物5-羟吲哚乙酸（5-HIAA）的脑脊液浓度与EPQ神经质得分显著相关。
结论
中枢血清素可能在神经质中起作用，神经质是一种易患抑郁症的人格维度。
局限性
正相关可能部分反映了两个变量与焦虑/抑郁之间的共线关系。
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