Bhattacharyya S N, Lynn W S
Biochim Biophys Acta. 1978 Dec 20;537(2):329-35. doi: 10.1016/0005-2795(78)90516-0.
A glycoprotein of the molecular weight of 36 000 has been isolated from human amniotic fluid. The glycoprotein was found to contain sialic acid, galactose, mannose, fucose, glucosamine, hydroxyproline and relatively high amounts of glycine. End-group analyses resulted in a single NH2-terminal residue indicating that the glycoprotein was homogeneous. The data indicate that this unique collagen-like glycoprotein, which is immunologically identical to a major alveolar glycoprotein found in alveoli of patients with alveolar proteinosis, is also a major protein in the human amniotic fluid. The idea that the pulmonary constituents enter the amniotic fluid cavity during fetal lung development is also confirmed by this report.
已从人羊水中分离出一种分子量为36000的糖蛋白。发现该糖蛋白含有唾液酸、半乳糖、甘露糖、岩藻糖、葡糖胺、羟脯氨酸以及相对大量的甘氨酸。末端基团分析得出单一的NH2末端残基，表明该糖蛋白是均一的。数据表明，这种独特的类胶原蛋白糖蛋白在免疫上与肺泡蛋白沉积症患者肺泡中发现的一种主要肺泡糖蛋白相同，它也是人羊水中的一种主要蛋白质。本报告也证实了在胎儿肺发育过程中肺部成分进入羊膜腔的观点。
