DNA结构：阳离子起主导作用？
DNA structure: cations in charge?
作者信息
McFail-Isom L, Sines C C, Williams L D
机构信息
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta 30332-0400, USA.
出版信息
Curr Opin Struct Biol. 1999 Jun;9(3):298-304. doi: 10.1016/S0959-440X(99)80040-2.
Recent X-ray diffraction, NMR spectroscopy and molecular mechanics results suggest that monovalent cations selectively partition into the minor groove of AT-tracts in DNA. These observations are consistent with DNA deformation by electrostatic collapse around areas of uneven cation density. This model predicts the occurrence of known DNA deformations, such as AT-tract bending and changes in the minor-groove width.
近期的X射线衍射、核磁共振光谱和分子力学研究结果表明，单价阳离子会选择性地分配到DNA中AT序列的小沟内。这些观察结果与阳离子密度不均区域周围的静电塌缩导致的DNA变形相一致。该模型预测了已知的DNA变形的发生，如AT序列弯曲和小沟宽度的变化。
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