Mitchell H K, Lipps L S
Cell. 1978 Nov;15(3):907-18. doi: 10.1016/0092-8674(78)90275-1.
Differentiation of the single cells that yield bristles and hairs in Drosophila has been examined by studies of phenocopies induced by heat shock. Phenocopies that resemble the mutants hook and javelin are produced by application of the stress within narrow and specific time ranges during metamorphosis. Double phenocopies can be induced by successive heat shocks at appropriate time intervals. Phenocopy production may be related to heat shock effects on RNA synthesis through a feedback inhibition of transcription by heat shock proteins.
通过对热休克诱导的拟表型进行研究，人们已经对果蝇中产生刚毛和毛发的单细胞分化进行了检测。在变态发育过程中的狭窄且特定的时间范围内施加应激，会产生类似于突变体钩状和标枪状的拟表型。通过在适当的时间间隔进行连续热休克，可以诱导出双重拟表型。拟表型的产生可能与热休克蛋白对转录的反馈抑制作用所导致的热休克对RNA合成的影响有关。
