Mitchell H K, Petersen N S
Dev Biol. 1983 Feb;95(2):459-67. doi: 10.1016/0012-1606(83)90047-7.
We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with rather sharp boundaries in between. In order to evaluate the basis for the gradient we studied two mutants which carry different combinations of the genes of the bithorax complex. These were examined with respect to the temporal aspects of sensitivity to heat shock induction of the multihair phenocopy on wings and the time of initiation of the program of protein synthesis that is related to hair formation. Results show that the gradient observed is based on predetermined properties within specific areas of tissue rather than on the position of the cells in the animal.
我们提供的证据表明，翅细胞分化产生刚毛在翅表面远端90%（约28,000个细胞）范围内是同步的。尽管在如此大的区域内存在同步性，但在动物体表的不同区域（通常从前到后）之间存在时间梯度，且其间界限相当清晰。为了评估这种梯度的基础，我们研究了两个携带双胸复合体不同基因组合的突变体。针对翅上多毛拟表型热休克诱导的时间敏感性以及与刚毛形成相关的蛋白质合成程序启动时间对这些突变体进行了检测。结果表明，观察到的梯度是基于组织特定区域内预先确定的特性，而非基于细胞在动物体内的位置。
