Traykov L, Rigaud A S, Caputo L, Couderc R, Coste J, Michot J L, de Rotrou J, Amouyel P, Forette F, Boller F
INSERM Unit 324, 2ter rue d'Alesia, 75014, Paris, France.
Eur J Neurol. 1999 Jul;6(4):415-21. doi: 10.1046/j.1468-1331.1999.640415.x.
Controversy exists regarding the apolipoprotein E (ApoE) epsilon4 allele association with vascular dementia (VaD), ranging from increased epsilon4 frequency, similar to that found for Alzheimer's disease (AD), to no association between the epsilon4 allele and VaD. To clarify further the relationship between ApoE alleles polymorphism and cerebrovascular disease (CVD) in demented and cognitively impaired patients, we examined the ApoE phenotypes in a sample of 280 patients: 155 with AD, 21 with VaD, 32 with mixed dementia (MD), 45 with mild cognitive impairment (MCI) but without CVD, and 27 in which vascular disease was the most probable cause of cognitive decline [vascular mild cognitive impairment (VMCI)]. Our results show that the frequency of the ApoE epsilon4 allele in patients over 70 years old with clinically diagnosed VaD and VMCI does not differ significantly from that of controls. In contrast, ApoE epsilon4 allele-bearing individuals had greater risk of having late-onset AD (OR = 8.8; 95% CI 3.7-21.0), or non-vascular cognitive impairment (OR = 7.0; 95% CI 2.5-19.0).
关于载脂蛋白E（ApoE）ε4等位基因与血管性痴呆（VaD）之间的关联存在争议，从ε4频率增加（类似于阿尔茨海默病（AD）中的情况）到ε4等位基因与VaD之间无关联。为了进一步阐明痴呆和认知障碍患者中ApoE等位基因多态性与脑血管疾病（CVD）之间的关系，我们检测了280例患者样本中的ApoE表型：155例AD患者、21例VaD患者、32例混合性痴呆（MD）患者、45例无CVD的轻度认知障碍（MCI）患者以及27例血管疾病最可能是认知衰退原因的患者[血管性轻度认知障碍（VMCI）]。我们的结果显示，临床诊断为VaD和VMCI的70岁以上患者中ApoE ε4等位基因的频率与对照组无显著差异。相比之下，携带ApoE ε4等位基因的个体患晚发性AD（OR = 8.8；95%CI 3.7 - 21.0）或非血管性认知障碍（OR = 7.0；95%CI 2.5 - 19.0）的风险更高。
