Kawaguchi K, Kikuchi S, Takayanagi K, Yoshikawa T, Kumazawa Y
Planta Med. 1999 May;65(4):365-6. doi: 10.1055/s-2006-960788.
To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.
为评估生物黄酮的免疫调节活性，对两种二氢黄酮、三种黄酮和三种黄酮醇的集落刺激因子（CSF）诱导活性进行了测试。将这些样品悬浮于生理盐水中，在采血前6小时以1毫克的剂量腹腔注射到小鼠体内。所有带有葡萄糖基鼠李糖部分的化合物均表现出较强的活性。其中，橙皮苷表现出最强的活性。注射1毫克橙皮苷的小鼠血清CSF产量在9小时后达到峰值。在0.3至20毫克/小鼠的范围内，橙皮苷的活性呈剂量依赖性。
