Magnusson I
Periodontal Disease Research Center, Department of Oral Biology, University of Florida, Gainesville, USA.
J Clin Periodontol. 1998 Nov;25(11 Pt 2):959-63; discussion 978-9. doi: 10.1111/j.1600-051x.1998.tb02398.x.
Local delivery of antimicrobials has been investigated as a possible method for controlling and treating periodontal disease. A number of antimicrobial agents have been studied both as adjunctive therapies with scaling and root planing and as stand-alone chemotherapies. More recent investigations have focussed on the delivery of antimicrobials in sustained-release formulations designed to maintain effective concentrations of drug within the periodontal pocket. This article provides an overview of the development of the use of locally-delivered metronidazole in periodontal therapy and the current state-of-the-art of the technique. It is concluded that treatment with local delivery of metronidazole seems to be as effective as scaling and root planing in untreated as well as in recall subjects. However, there are reasons to suggest that local delivery of metronidazole should not be used as a substitute for conventional treatment of periodontal disease, since side-effects of long-term use and repeated use are not known. The antibiotic regimen should preferably be used as an adjunct to surgical and non-surgical therapy.
抗菌剂的局部递送已作为控制和治疗牙周疾病的一种可能方法进行了研究。许多抗菌剂已作为龈上洁治术和根面平整术的辅助治疗方法以及单独的化学疗法进行了研究。最近的研究集中在以缓释制剂形式递送抗菌剂，旨在在牙周袋内维持有效的药物浓度。本文概述了局部递送甲硝唑在牙周治疗中的应用发展以及该技术的当前技术水平。得出的结论是，在未经治疗的患者以及复诊患者中，局部递送甲硝唑治疗似乎与龈上洁治术和根面平整术一样有效。然而，有理由表明，甲硝唑的局部递送不应作为牙周疾病传统治疗的替代方法，因为长期使用和重复使用的副作用尚不清楚。抗生素疗法最好用作手术和非手术治疗的辅助手段。
