组胺诱导促甲状腺激素释放激素从下丘脑切片中释放。
Histamine-induced release of thyrotropin releasing hormone from hypothalamic slices.
作者信息
Charli J L, Joseph-Bravo P, Palacios J M, Kordon C
出版信息
Eur J Pharmacol. 1978 Dec 1;52(3-4):401-3. doi: 10.1016/0014-2999(78)90298-4.
In vitro release of TRH from mediobasal hypothalamic (MBH) slices was increased in the presence of 56 mM K+ in a Ca2+-dependent manner. Addition of histamine (HA) induced a concentration-dependent release of TRH; concentrations of 3 x 10(-7) M and 10(-6) M elicited maximal and maximal stimulation respectively. Cimetidine 10(-6) M, a potent antagonist of HA H2-receptors, inhibited the effect of HA. The present results suggest that HA can trigger the release of TRH from neurosecretory nerve endings and that MBH slices are a useful preparation for studying neurohormone release.
在56 mM K⁺存在的情况下，促甲状腺激素释放激素（TRH）从下丘脑中间基底部（MBH）切片的体外释放以Ca²⁺依赖的方式增加。组胺（HA）的添加诱导了TRH的浓度依赖性释放；3×10⁻⁷ M和10⁻⁶ M的浓度分别引起最大和最大刺激。10⁻⁶ M的西咪替丁，一种HA H2受体的强效拮抗剂，抑制了HA的作用。目前的结果表明，HA可以触发神经分泌神经末梢释放TRH，并且MBH切片是研究神经激素释放的有用制剂。
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