仙人掌中某些三萜类化合物对由12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯促进的32Pi掺入HeLa细胞磷脂的抑制作用。
Inhibitory effect of some triterpenes from cacti on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoylphorbol-13-acetate.
作者信息
Kinoshita K, Yang Y, Koyama K, Takahashi K, Nishino H
机构信息
Department of Pharmacognocy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
出版信息
Phytomedicine. 1999 May;6(2):73-7. doi: 10.1016/s0944-7113(99)80038-5.
Seventeen triterpenes isolated from cacti and the 10 derivatives were examined for the inhibition of tumor promoter-induced effects in vitro, such as stimulation of 32Pi-incorporation into phospholipids of cultured cells. Betulinic acid (1), cochalic acid (15), erythrodiol (16), oleanolic acid (21) and queretaroic acid (24) inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated 32Pi-incorporation into phospholipids of the cultured cells.
对从仙人掌中分离出的17种三萜类化合物及其10种衍生物进行了体外抑制肿瘤启动子诱导效应的研究，例如抑制32P掺入培养细胞磷脂中的作用。桦木酸（1）、柯卡利酸（15）、赤藓醇（16）、齐墩果酸（21）和克雷塔罗酸（24）抑制了12-O-十四酰佛波醇-13-乙酸酯（TPA）刺激的32P掺入培养细胞磷脂中的过程。
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