Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus.
作者信息
Takayasu J, Tanaka R, Matsunaga S, Ueyama H, Tokuda H, Hasegawa T, Nishino A, Nishino H, Iwashima A
机构信息
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
出版信息
Cancer Lett. 1990 Sep;53(2-3):141-4. doi: 10.1016/0304-3835(90)90206-d.
PMID:2208073
Abstract
Abiesenonic acid methyl ester (AVB-I acid methyl ester), a triterpenoid compound prepared from abieslactone, suppressed tumor promoter-induced phenomena in vitro and in vivo; i.e., AVB-I acid methyl ester inhibited 12-o-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells and the promoting action of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
摘要
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