[3,4,5-三羟基二苯乙烯-3-β-D-葡萄糖苷对家兔血小板聚集及血栓素B2体外生成的影响]
[Influences of 3,4,5-trihydroxystibene-3-beta-mono-D-glucoside on rabbits' platelet aggregation and thromboxane B2 production in vitro].
作者信息
Shan C W, Yang S Q, He H D, Shao S L, Zhang P W
机构信息
Department of Pharmacology, First Military Medical College, Guangzhou, China.
出版信息
Zhongguo Yao Li Xue Bao. 1990 Nov;11(6):527-30.
Platelet aggregation and thromboxane B2 (TXB2) production induced by arachidonic acid (AA) or Adenosine diphosphate (ADP) were studied by turbidimetry and radioimmunoassay in rabbits. 3,4,5-tri-hydroxystibene-3-beta-mono-D-glucoside (PD) 6.7-107.2 mumol/L inhibited platelet aggregation and the production of TXB2 as well. The inhibitions by PD were dose-dependent: 48-90% (AA-induced) and 43-69% (ADP-induced) for platelet aggregation; 50-87% (AA-induced) and 43-68% (ADP-induced) for TXB2. There were positive correlations between the inhibition of platelet aggregation and production of TXB2.
通过比浊法和放射免疫分析法研究了花生四烯酸（AA）或二磷酸腺苷（ADP）诱导的家兔血小板聚集和血栓素B2（TXB2）生成情况。3,4,5-三羟基二苯乙烯-3-β-D-葡萄糖苷（PD）6.7-107.2μmol/L可抑制血小板聚集以及TXB2的生成。PD的抑制作用呈剂量依赖性：对血小板聚集的抑制率为48%-90%（AA诱导）和43%-69%（ADP诱导）；对TXB2的抑制率为50%-87%（AA诱导）和43%-68%（ADP诱导）。血小板聚集抑制率与TXB2生成抑制率之间存在正相关。
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