Davis L S, Schulze-Koops H, Lipsky P E
UT Southwestern Medical Center, Department of Internal Medicine, Dallas, TX 75235-8884, USA.
Immunol Res. 1999;19(1):25-34. doi: 10.1007/BF02786474.
Human CD4+ memory T cells progress through stages of postthymic differentiation that have been characterized by distinct phenotypes. We have investigated the factors regulating cytokine production, and the correlation between phenotype and effector function in normal and autoimmune individuals. These studies suggest that antigen-induced proliferation in the periphery drives CD4+ T cells through successive stages of differentiation that culminate in optimal effector function and resistance to external modulatory influences. Moreover, these studies support the concept that in autoimmune individuals, the chronic accumulation of differentiated proinflammatory T cells perpetuate the inflammatory response resulting in aggressive disease.
人类CD4+记忆性T细胞经历胸腺后分化阶段，这些阶段具有不同的表型特征。我们研究了正常个体和自身免疫个体中调节细胞因子产生的因素，以及表型与效应器功能之间的相关性。这些研究表明，外周抗原诱导的增殖驱动CD4+T细胞经历连续的分化阶段，最终达到最佳效应器功能并抵抗外部调节影响。此外，这些研究支持这样一种观点，即在自身免疫个体中，分化的促炎T细胞的慢性积累使炎症反应持续存在，导致侵袭性疾病。
