Adv Exp Med Biol. 2011;780:57-68. doi: 10.1007/978-1-4419-5632-3_6.
How memory CD4 T cells contribute to protection upon pathogen -challenge is not fully understood. Beyond traditional helper functions for CD8 T cell and B cell responses, memory CD4 T cells can have a potent impact on the character and a magnitude of inflammatory responses. Here we discuss how memory CD4 T cell control of innate immunity at early time points after pathogen encounters can influence protective responses. We also discuss important aspects of the mechanism whereby memory CD4 T cells directly and indirectly impact the activation status of antigen-presenting cells and production of inflammatory cytokines and chemokines from multiple cell types. We suggest that control of innate immune responses by the adaptive immune system is a powerful protective mechanism associated with the memory state and represents an important fail-safe in the face of pathogens that fail to trigger robust inflammatory responses through conserved pattern recognition receptors.
记忆 CD4 T 细胞如何有助于病原体攻击后的保护作用尚不完全清楚。除了对 CD8 T 细胞和 B 细胞反应的传统辅助功能外，记忆 CD4 T 细胞还可以对炎症反应的特征和程度产生重大影响。在这里，我们讨论了记忆 CD4 T 细胞在病原体接触后早期控制先天免疫如何影响保护性反应。我们还讨论了记忆 CD4 T 细胞直接和间接影响抗原呈递细胞激活状态以及多种细胞类型产生炎症细胞因子和趋化因子的机制的重要方面。我们认为，适应性免疫系统对先天免疫反应的控制是一种与记忆状态相关的强大保护机制，代表了在面对未能通过保守模式识别受体引发强烈炎症反应的病原体时的重要故障安全机制。
