人单核细胞U937细胞在体外通过不依赖一氧化氮的机制杀死沙门氏菌。
Human monocytic U937 cells kill Salmonella in vitro by NO-independent mechanisms.
作者信息
Ekman P, Saarinen M, He Q, Virtala M, Salmi M, Granfors K
机构信息
National Public Health Institute, Department in Turku, Turku, Finland.
出版信息
Infect Immun. 1999 Jul;67(7):3670-3. doi: 10.1128/IAI.67.7.3670-3673.1999.
Abstract
Nitric oxide (NO) has a central role in host defense against intracellular microbes. HLA-B27 has been shown to directly modulate host-microbe interaction in vitro, leading to the impaired elimination of Salmonella in human monocytic U937 cells. Here, we studied whether impaired elimination of Salmonella would result from differences in NO production between HLA-B27- and HLA-A2-transfected U937 cells. Both human monocytic transfectants produced NO equally well and killed Salmonella via NO-independent mechanisms.
摘要
一氧化氮（NO）在宿主抵御细胞内微生物的防御过程中发挥着核心作用。已有研究表明，HLA - B27在体外可直接调节宿主与微生物的相互作用，导致人单核细胞U937细胞中沙门氏菌的清除受损。在此，我们研究了HLA - B27转染的U937细胞和HLA - A2转染的U937细胞之间NO产生的差异是否会导致沙门氏菌清除受损。两种人单核细胞转染体产生NO的能力相同，并通过不依赖NO的机制杀死沙门氏菌。
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