JC病毒DNA存在于人类结肠黏膜及结直肠癌中。
JC virus DNA is present in the mucosa of the human colon and in colorectal cancers.
作者信息
Laghi L, Randolph A E, Chauhan D P, Marra G, Major E O, Neel J V, Boland C R
机构信息
Department of Medicine and Cancer Center, University of California, San Diego, 4028 Basic Science Building, 9500 Gilman Drive, La Jolla, CA, 92093-0688, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7484-9. doi: 10.1073/pnas.96.13.7484.
Abstract
JC virus (JCV) is a polyoma virus that commonly infects humans. We have found T antigen DNA sequences of JCV in the mucosa of normal human colons, colorectal cancers, colorectal cancer xenografts raised in nude mice, and in the human colon cancer cell line SW480. A larger number of viral copies is present in cancer cells than in non-neoplastic colon cells, and sequence microheterogeneity occurs within individual colonic mucosal specimens. The improved yield of detection after treatment with topoisomerase I suggests that the viral DNA is negatively supercoiled in the human tissues. These results indicate that JCV DNA can be found in colonic tissues, which raises the possibility that this virus may play a role in the chromosomal instability observed in colorectal carcinogenesis.
摘要
JC病毒（JCV）是一种常见感染人类的多瘤病毒。我们在正常人结肠黏膜、结直肠癌、裸鼠体内培养的结直肠癌异种移植瘤以及人结肠癌细胞系SW480中发现了JCV的T抗原DNA序列。癌细胞中的病毒拷贝数比非肿瘤性结肠细胞中的多，并且在单个结肠黏膜标本中存在序列微异质性。用拓扑异构酶I处理后检测产量的提高表明病毒DNA在人体组织中呈负超螺旋状态。这些结果表明JCV DNA可在结肠组织中发现，这增加了该病毒可能在结直肠癌发生过程中观察到的染色体不稳定性中起作用的可能性。
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