Marongiu Luigi, Venturelli Sascha, Allgayer Heike
Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht-Karls University of Heidelberg, Ludolf-Krehl-Str. 13-17, 68167 Mannheim, Germany.
Department of Internal Medicine VIII, University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076 Tübingen, Germany.
Cancers (Basel). 2022 Oct 17;14(20):5085. doi: 10.3390/cancers14205085.
Gastrointestinal diseases (GDs) include colorectal cancer (CRC), gastric cancer (GC), and inflammatory bowel disease (IBD). CRC and GC are typically diagnosed at later stages of development, reducing patients' chances of survival. IBD is characterized by chronic intestinal inflammation and is a significant risk factor for the development of CRC. Chronic bacterial infections have been shown to promote some GDs, but the role of viruses in the etiology of these diseases is less clear. The present meta-analysis retrieved literature on the viral prevalence in GD patients, measuring the GD risk in odd ratios. By quantifying the study heterogeneity, the literature bias was fundamentally included in the analysis. The analysis also included 11 metagenomic studies. Our meta-analysis retrieved 11,413 studies, with 196 suitable for analysis. HHV-4 (Epstein-Barr virus) was identified as a significant risk factor for the development of IBD, and HHV-5 (cytomegalovirus) as a risk factor for both CRC and IBD. Polyomaviruses and the Hepatitis B virus were also, less strongly, involved in the risk of CRC and IBD. No relations withstanding the literature bias were identified for GC. The study discusses these findings, as well as the role of other viruses in the etiology of CRC and IBD.
胃肠道疾病（GDs）包括结直肠癌（CRC）、胃癌（GC）和炎症性肠病（IBD）。结直肠癌和胃癌通常在疾病发展的后期才被诊断出来，这降低了患者的生存几率。炎症性肠病的特征是肠道慢性炎症，是结直肠癌发生的一个重要风险因素。已表明慢性细菌感染会促进某些胃肠道疾病的发生，但病毒在这些疾病病因中的作用尚不清楚。本荟萃分析检索了关于胃肠道疾病患者病毒流行情况的文献，以比值比衡量胃肠道疾病风险。通过量化研究的异质性，从根本上在分析中纳入了文献偏倚。该分析还包括11项宏基因组学研究。我们的荟萃分析检索到11413项研究，其中196项适合分析。HHV - 4（爱泼斯坦 - 巴尔病毒）被确定为炎症性肠病发生的一个重要风险因素，HHV - 5（巨细胞病毒）是结直肠癌和炎症性肠病的风险因素。多瘤病毒和乙型肝炎病毒在结直肠癌和炎症性肠病的风险中也有较弱的关联。未发现与胃癌相关的不受文献偏倚影响的关系。该研究讨论了这些发现以及其他病毒在结直肠癌和炎症性肠病病因中的作用。
