Kermarrec N, Roubinet F, Apoil P A, Blancher A
Laboratoire d'Immunohématologie, Etablissement de Transfusion Sanguine Pyrénées-Garonne, Toulouse, France.
Immunogenetics. 1999 Jun;49(6):517-26. doi: 10.1007/s002510050529.
Like humans, non-human primates express the antigens A and B of the ABO histoblood group system. In chimpanzees, only A and O types are found, while the types A, B, AB, and O are found in macaques. The sequences of exons 6 and 7 of two chimpanzee O alleles (Odel and O(x), two macaque species O alleles (rhesus monkey and crab-eating macaque), and sequences of exon 7 of two major chimpanzee A alleles (A1ch and A2ch) were established. The sequences of cDNAs corresponding to the chimpanzee and rhesus monkey O alleles were characterized from exon 1 to 7 and from exon 4 to 7, respectively. A comparison of our results with ABO gene sequences already published by others demonstrates that human and non-human primate O alleles are species-specific and result from independent silencing mutations. These observations reinforce the hypothesis that the maintenance of the ABO gene polymorphism in primates reflects convergent evolution more than transpecies inheritance of ancestor alleles.
与人类一样，非人灵长类动物也表达ABO组织血型系统的A和B抗原。在黑猩猩中，只发现了A和O型，而猕猴中则发现了A、B、AB和O型。确定了两个黑猩猩O等位基因（Odel和O(x)）、两个猕猴物种O等位基因（恒河猴和食蟹猕猴）的外显子6和7的序列，以及两个主要黑猩猩A等位基因（A1ch和A2ch）的外显子7的序列。分别从外显子1至7和外显子4至7对与黑猩猩和恒河猴O等位基因对应的cDNA序列进行了表征。将我们的结果与其他人已发表的ABO基因序列进行比较表明，人类和非人灵长类动物的O等位基因具有物种特异性，是独立沉默突变的结果。这些观察结果强化了这样一种假设，即灵长类动物中ABO基因多态性的维持反映的是趋同进化，而非祖先等位基因的跨物种遗传。
