McLaughlin R, Kin N M, Chen M F, Nair N P, Chan E C
Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Neuroreport. 1999 May 14;10(7):1489-91. doi: 10.1097/00001756-199905140-00018.
It has been reported previously that spirochetes could be one of the causes of Alzheimer's disease (AD). In this study, we have attempted to reproduce these findings by examining fresh blood samples from 22 patients diagnosed with early stage (n = 16) and late stage (n = 6) AD. The patients were participants in a clinical drug trial. Fresh necropsy brain cortical specimens from AD patients (n = 7) were also examined. Spirochetes were observed microscopically in the blood of only one late-stage AD patient. None of the brain tissues showed the presence of spirochetes. Our results suggest that spirochetes are probably not associated with AD.
先前已有报道称，螺旋体可能是阿尔茨海默病（AD）的病因之一。在本研究中，我们试图通过检测22例被诊断为早期（n = 16）和晚期（n = 6）AD患者的新鲜血液样本重现这些发现。这些患者是一项临床药物试验的参与者。我们还检测了7例AD患者新鲜尸检的脑皮质标本。仅在1例晚期AD患者的血液中通过显微镜观察到螺旋体。所有脑组织均未显示存在螺旋体。我们的结果表明，螺旋体可能与AD无关。
