Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA.
Laboratory of Clinical Microbiology and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Clin Infect Dis. 2022 Aug 25;75(2):342-346. doi: 10.1093/cid/ciab993.
The role that microorganisms might have in the development of Alzheimer disease is a topic of considerable interest. In this article, we discuss whether there is credible evidence that Lyme disease is a cause of Alzheimer disease and critically review a recent publication that claimed that Borrelia burgdorferi sensu stricto infection, the primary cause of Lyme disease in the United States, may cause Lewy body dementia. We conclude that no convincing evidence exists that Lyme disease is a cause of either Alzheimer disease or Lewy body dementia.
微生物在阿尔茨海默病发展中可能发挥的作用是一个备受关注的话题。在本文中，我们讨论了莱姆病是否有可信的证据表明其是阿尔茨海默病的病因，并批判性地回顾了最近的一篇声称，在美国莱姆病的主要病因伯氏疏螺旋体感染可能导致路易体痴呆的出版物。我们的结论是，没有令人信服的证据表明莱姆病是阿尔茨海默病或路易体痴呆的病因。
