Longman R J, Thomas M G, Poulsom R
University Department of Surgery, Bristol Royal Infirmary, UK.
Br J Surg. 1999 Jun;86(6):740-8. doi: 10.1046/j.1365-2168.1999.01131.x.
Trefoil peptides are a family of small proteins that are expressed in a site-specific fashion by certain epithelial tissues. These peptides appear to be important in mucosal healing processes and in neoplastic disease.
This manuscript reviews the relevant literature obtained by an extensive text word search of the Medline database and a manual search of references from the articles identified.
Trefoil peptides are aberrantly expressed by a wide range of human carcinomas and gastrointestinal inflammatory conditions. They impart protection from injury to the gastrointestinal mucosa by possible interaction with mucin glycoproteins. Trefoil peptides influence epithelial cell migration and mucosal restitution following injury. In the future, serum levels of trefoil peptides might be used as markers for both neoplastic and inflammatory diseases. In addition, novel therapies based on such peptides might be used for gastrointestinal inflammatory conditions and to accelerate repair of the gastrointestinal mucosa after surgery.
三叶肽是一类小蛋白质家族，由某些上皮组织以位点特异性方式表达。这些肽在黏膜愈合过程和肿瘤疾病中似乎很重要。
本手稿回顾了通过对Medline数据库进行广泛文本词搜索以及对所识别文章的参考文献进行人工搜索而获得的相关文献。
三叶肽在多种人类癌症和胃肠道炎症性疾病中异常表达。它们可能通过与粘蛋白糖蛋白相互作用来保护胃肠道黏膜免受损伤。三叶肽影响损伤后上皮细胞迁移和黏膜修复。未来，三叶肽的血清水平可能用作肿瘤和炎症性疾病的标志物。此外，基于此类肽的新型疗法可能用于胃肠道炎症性疾病，并加速术后胃肠道黏膜的修复。
