Vallet-Regí M, Izquierdo-Barba I, Salinas A J
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, E-28040-Madrid, Spain.
J Biomed Mater Res. 1999 Sep 15;46(4):560-5. doi: 10.1002/(sici)1097-4636(19990915)46:4<560::aid-jbm14>3.0.co;2-m.
Two sol-gel glasses with 80 mol % SiO2 were prepared in the system SiO2-CaO-P2O5; the first one had 3 mol% P2O5 in its composition, and the second one was P2O5 free. The in vitro behavior of glasses was studied by soaking them in simulated body fluid for 7 days at 37 degrees C. After the in vitro test, the study by Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, electron diffraction, and transmission electron microscopy showed an apatite-like layer had formed on the surface of both glasses. However, for identical soaking time, the apatite crystals formed on the surface of the glass containing P2O5 in the composition were larger. Therefore, the presence of P2O5 in the sol-gel glass composition promotes the crystal growth of the apatite.
在SiO2-CaO-P2O5体系中制备了两种SiO2含量为80摩尔%的溶胶-凝胶玻璃；第一种玻璃成分中含有3摩尔%的P2O5，第二种玻璃不含P2O5。通过将玻璃在37℃的模拟体液中浸泡7天来研究其体外行为。体外试验后，通过傅里叶变换红外光谱、扫描电子显微镜、能谱、电子衍射和透射电子显微镜研究表明，两种玻璃表面均形成了类磷灰石层。然而，在相同的浸泡时间下，成分中含有P2O5的玻璃表面形成的磷灰石晶体更大。因此，溶胶-凝胶玻璃成分中P2O5的存在促进了磷灰石的晶体生长。
