Fraulini Francesca, Raimondi Stefano, Candeliere Francesco, Ranieri Raffaella, Zambon Alfonso, Lusvardi Gigliola
Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
J Funct Biomater. 2023 Feb 26;14(3):129. doi: 10.3390/jfb14030129.
Mesoporous Bioactive Glasses (MBGs) are biomaterials widely used in tissue engineering, particularly for hard tissue regeneration. One of the most frequent postoperative complications following a biomaterial surgical implant is a bacterial infection, which usually requires treatment by the systemic administration of drugs (e.g., antibiotics). In order to develop biomaterials with antibiotic properties, we investigated cerium-doped MBGs (Ce-MBGs) as in situ-controlled drug delivery systems (DDSs) of gentamicin (Gen), a wide spectrum antibiotic commonly employed against bacteria responsible of postoperative infections. Here we report the optimization of Gen loading on MBGs and the evaluation of the antibacterial properties and of retention of bioactivity and antioxidant properties of the resulting materials. The Gen loading (up to 7%) was found to be independent from cerium content, and the optimized Gen-loaded Ce-MBGs retain significant bioactivity and antioxidant properties. The antibacterial efficacy was verified up to 10 days of controlled release. These properties make Gen-loaded Ce-MBGs interesting candidates for simultaneous hard tissue regeneration and in situ antibiotic release.
介孔生物活性玻璃（MBG）是广泛应用于组织工程的生物材料，尤其用于硬组织再生。生物材料手术植入后最常见的术后并发症之一是细菌感染，通常需要通过全身给药（如抗生素）进行治疗。为了开发具有抗生素特性的生物材料，我们研究了铈掺杂的MBG（Ce-MBG）作为庆大霉素（Gen）的原位控制药物递送系统（DDS），庆大霉素是一种常用于对抗导致术后感染的细菌的广谱抗生素。在此，我们报告了MBG上Gen负载的优化以及所得材料的抗菌性能、生物活性保留和抗氧化性能的评估。发现Gen负载量（高达7%）与铈含量无关，优化后的负载Gen的Ce-MBG保留了显著的生物活性和抗氧化性能。在10天的控释过程中验证了抗菌效果。这些特性使负载Gen的Ce-MBG成为同时进行硬组织再生和原位抗生素释放的有趣候选材料。
