常染色体显性多囊肾病患者卵巢囊肿的发生率

Frequency of ovarian cysts in patients with autosomal dominant polycystic kidney disease.

作者信息

Stamm E R, Townsend R R, Johnson A M, Garg K, Manco-Johnson M, Gabow P A

机构信息

Departments of Medicine and Radiology, University of Colorado Health Sciences Center, Denver, CO, USA.

出版信息

Am J Kidney Dis. 1999 Jul;34(1):120-4. doi: 10.1016/s0272-6386(99)70117-4.

DOI:10.1016/s0272-6386(99)70117-4

PMID:10401025

Abstract

Extrarenal cysts occur in patients with autosomal dominant polycystic kidney disease (ADPKD) most frequently in the liver. Ovarian cysts have been reported in women with ADPKD, but their frequency has not been determined. Therefore, we analyzed the historical data in our database of 337 women with ADPKD and 199 of their unaffected female family members (NADPKD). In addition, we prospectively studied 25 nonpregnant, premenopausal women with ADPKD and 25 nonpregnant, premenopausal, age-matched control women recruited from the general population to assess the occurrence of ovarian cysts. No women in either the control or ADPKD groups were receiving exogenous estrogen or progesterone. All women underwent sonographic examination using a 5- or 7.5-MHz vaginal probe. A normal ovarian follicle was defined as a fluid-filled structure less than 2 cm in average diameter, and an ovarian cyst as one of 2 cm or greater. From the historical data, 28% of the women with ADPKD gave a history of ovarian cysts compared with 18% of the NADPKD women (P < 0.05). In the prospective study, the mean age of the women with ADPKD was not different from that of the control women (40.9 +/- 1.2 v 39.3 +/- 1.2 years; P = not significant [NS]). There was no difference in frequency of normal follicles found in women with ADPKD or controls (80% v 96%; P = NS), nor was there a difference in the frequency of ovarian cysts found in women with ADPKD or controls (12% v 12%; P = NS). There was no difference in the calculated ovarian volumes between the women with ADPKD and controls (9.9 +/- 2. 5 v 7.2 +/- 1.2 cm3). Among the women with ADPKD, there was no correlation between mean ovarian volume and mean renal volume, nor was there a significant relationship between the occurrence of hepatic cystic disease and ovarian cysts. Therefore, a prospective imaging study suggests that ovarian cysts have no increased frequency in women with ADPKD compared with women in the general population.

摘要

肾外囊肿最常见于常染色体显性多囊肾病（ADPKD）患者的肝脏。有报道称ADPKD女性患者存在卵巢囊肿，但尚未确定其发生率。因此，我们分析了我们数据库中337例ADPKD女性患者及其199名未患病女性家庭成员（非ADPKD）的历史数据。此外，我们前瞻性地研究了25例非妊娠、绝经前的ADPKD女性患者以及从普通人群中招募的25例年龄匹配的非妊娠、绝经前对照女性，以评估卵巢囊肿的发生情况。对照组和ADPKD组的女性均未接受外源性雌激素或孕激素治疗。所有女性均使用5或7.5兆赫的阴道探头进行超声检查。正常卵巢卵泡定义为平均直径小于2厘米的充满液体的结构，卵巢囊肿定义为直径2厘米或更大的结构。根据历史数据，28%的ADPKD女性有卵巢囊肿病史，而非ADPKD女性为18%（P<0.05）。在前瞻性研究中，ADPKD女性的平均年龄与对照女性无差异（40.9±1.2岁对39.3±1.2岁；P=无显著性差异[NS]）。ADPKD女性或对照女性中发现正常卵泡的频率无差异（80%对96%；P=NS），ADPKD女性或对照女性中发现卵巢囊肿的频率也无差异（12%对~12%；P=NS）。ADPKD女性与对照女性的计算卵巢体积无差异（9.9±2.5立方厘米对7.2±1.2立方厘米）。在ADPKD女性中，平均卵巢体积与平均肾体积之间无相关性，肝囊肿疾病的发生与卵巢囊肿之间也无显著关系。因此，一项前瞻性影像学研究表明，与普通人群中的女性相比，ADPKD女性卵巢囊肿的发生率并未增加。