精神分裂症患者小脑和蚓部的定量容积磁共振成像研究：临床及认知相关性
Quantitative volumetric MRI study of the cerebellum and vermis in schizophrenia: clinical and cognitive correlates.
作者信息
Levitt J J, McCarley R W, Nestor P G, Petrescu C, Donnino R, Hirayasu Y, Kikinis R, Jolesz F A, Shenton M E
机构信息
Clinical Neuroscience Division, Harvard Medical School, Brockton/West Roxbury Veterans Affairs Medical Center, Boston, MA, USA.
出版信息
Am J Psychiatry. 1999 Jul;156(7):1105-7. doi: 10.1176/ajp.156.7.1105.
Abstract
OBJECTIVE
Recent evidence suggests that the cerebellum may play a role in higher cognitive functions and, therefore, may play an important role in schizophrenia.
METHOD
The authors used magnetic resonance imaging to measure cerebellum and vermis volume in 15 patients with schizophrenia and 15 normal comparison subjects.
RESULTS
They found that 1) vermis volume was greater in patients with schizophrenia than in normal subjects, 2) greater vermis white matter volume in the patients with schizophrenia significantly correlated with severity of positive symptoms and thought disorder and with impairment in verbal logical memory, and 3) patients with schizophrenia showed a trend for more cerebellar hemispheric volume asymmetry (left greater than right).
CONCLUSIONS
These data suggest that an abnormality in the vermis may contribute to the pathophysiology of schizophrenia.
摘要
目的
近期证据表明，小脑可能在高级认知功能中发挥作用，因此可能在精神分裂症中起重要作用。
方法
作者使用磁共振成像测量了15名精神分裂症患者和15名正常对照者的小脑和蚓部体积。
结果
他们发现，1）精神分裂症患者的蚓部体积大于正常受试者；2）精神分裂症患者较大的蚓部白质体积与阳性症状和思维障碍的严重程度以及言语逻辑记忆受损显著相关；3）精神分裂症患者显示出小脑半球体积不对称更明显的趋势（左侧大于右侧）。
结论
这些数据表明，蚓部异常可能导致精神分裂症的病理生理学改变。
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