各种吸入麻醉药的副交感神经反射性血管舒张抑制程度与最低肺泡有效浓度（MAC）值之间的相关性。

Correlation between degree of inhibition of parasympathetic reflex vasodilation and MAC value for various inhalation anesthetics.

作者信息

Izumi H, Ito Y

机构信息

Department of Physiology, Tohoku University School of Dentistry, Sendai, Japan.

出版信息

Gen Pharmacol. 1999 Jun;32(6):689-93. doi: 10.1016/s0306-3623(98)00242-0.

DOI:10.1016/s0306-3623(98)00242-0

PMID:10401994

Abstract

Parasympathetic reflex vasodilation was elicited in the lower lip by stimulation of the central cut end of the lingual nerve in urethane plus alpha-chloralose-anesthetized, vago-sympathectomized cats. A dose-related inhibition of this response was induced by the inhalation anesthetics isoflurane, halothane, sevoflurane, and enflurane, the ID50 values being 0.94%, 0.82%, 1.74%, and 2.0%, respectively. These results indicate that the ID50 value is approximately two-thirds of the published MAC (for isoflurane, halothane, sevoflurane, and enflurane, 1.6%, 1.2%, 2.6%, and 2.4%, respectively) value for such anesthetics, suggesting that parasympathetic reflex vasodilation is more susceptible than somato-somatic reflexes to inhibition by inhalation anesthetics.

摘要

在氨基甲酸乙酯加α-氯醛糖麻醉、迷走神经交感神经切除的猫中，通过刺激舌神经的中枢切断端，在下唇诱发副交感神经反射性血管舒张。吸入麻醉药异氟烷、氟烷、七氟烷和恩氟烷可诱导该反应的剂量相关抑制，ID50值分别为0.94%、0.82%、1.74%和2.0%。这些结果表明，ID50值约为这些麻醉药已公布的MAC值（异氟烷、氟烷、七氟烷和恩氟烷分别为1.6%、1.2%、2.6%和2.4%）的三分之二，提示副交感神经反射性血管舒张比躯体-躯体反射对吸入麻醉药的抑制更敏感。