Hikasa Y, Ohe N, Takase K, Ogasawara S
Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Japan.
Res Vet Sci. 1997 Nov-Dec;63(3):205-10. doi: 10.1016/s0034-5288(97)90021-7.
The cardiopulmonary effects of sevoflurane (mean, 2.6, 3.8-3.9 and 5.2 per cent) were compared with those of halothane (1.2, 1.8 and 2.4 per cent), enflurane (2.4, 3.6 and 4.8 per cent) and isoflurane (1.6, 2.4 and 3.2-3.3 per cent) at end-tidal concentrations equivalent to 1, 1.5 and 2 minimal alveolar concentrations (MACs) during spontaneous or controlled ventilation (SV or CV) in 57 cats. Cats were assigned to four groups of nine animals each in SV trial and four groups of five or six animals each in CV trial. During SV, respiration rate was decreased by sevoflurane and isoflurane at 2 MAC and by enflurane at each MAC multiple when compared with control values, whereas halothane increased respiration rate at 2 MAC. The degree of hypercapnia and acidosis induced by sevoflurane was not different from that induced by isoflurane and was less than that induced by halothane at 1 to 1.5 MAC or enflurane at 2 MAC. During SV and CV, four anaesthetics decreased heart rate at 2 MAC when compared with control values, but there was no significant difference between anaesthetics. Sevoflurane, like halothane and isoflurane, induced hypotension at 2 MAC when compared with 1 MAC.
在57只猫中，在自主通气或控制通气（SV或CV）期间，将七氟醚（分别为2.6%、3.8 - 3.9%和5.2%）的心肺效应与氟烷（1.2%、1.8%和2.4%）、恩氟烷（2.4%、3.6%和4.8%）及异氟烷（1.6%、2.4%和3.2 - 3.3%）在相当于1、1.5和2倍最低肺泡有效浓度（MAC）的呼气末浓度时的心肺效应进行比较。在SV试验中，猫被分为四组，每组9只动物；在CV试验中，猫被分为四组，每组5或6只动物。在SV期间，与对照值相比，七氟醚和异氟烷在2倍MAC时可降低呼吸频率，恩氟烷在每个MAC倍数时均可降低呼吸频率，而氟烷在2倍MAC时可增加呼吸频率。七氟醚诱导的高碳酸血症和酸中毒程度与异氟烷诱导的无差异，且在1至1.5倍MAC时低于氟烷诱导的程度，在2倍MAC时低于恩氟烷诱导的程度。在SV和CV期间，与对照值相比，四种麻醉剂在2倍MAC时均降低心率，但各麻醉剂之间无显著差异。与1倍MAC相比，七氟醚与氟烷和异氟烷一样，在2倍MAC时可诱导低血压。
