调控拟南芥表皮毛分化和花青素生物合成的透明种皮光滑1基因座编码一种WD40重复蛋白。
The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein.
作者信息
Walker A R, Davison P A, Bolognesi-Winfield A C, James C M, Srinivasan N, Blundell T L, Esch J J, Marks M D, Gray J C
机构信息
Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom.
出版信息
Plant Cell. 1999 Jul;11(7):1337-50. doi: 10.1105/tpc.11.7.1337.
The TRANSPARENT TESTA GLABRA1 (TTG1) locus regulates several developmental and biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and roots, and the production of seed mucilage and anthocyanin pigments. The TTG1 locus has been isolated by positional cloning, and its identity was confirmed by complementation of a ttg1 mutant. The locus encodes a protein of 341 amino acid residues with four WD40 repeats. The protein is similar to AN11, a regulator of anthocyanin biosynthesis in petunia, and more distantly related to those of the beta subunits of heterotrimeric G proteins, which suggests a role for TTG1 in signal transduction to downstream transcription factors. The 1.5-kb TTG1 transcript is present in all major organs of Arabidopsis. Sequence analysis of six mutant alleles has identified base changes producing truncations or single amino acid changes in the TTG1 protein.
透明种皮无毛1（TTG1）位点调控拟南芥中的几种发育和生化途径，包括叶、茎和根上毛状体的形成，以及种子黏液和花青素色素的产生。通过图位克隆分离出了TTG1位点，并通过对ttg1突变体的互补验证了其身份。该位点编码一个含有四个WD40重复序列的341个氨基酸残基的蛋白质。该蛋白质与矮牵牛中花青素生物合成的调节因子AN11相似，与异源三聚体G蛋白β亚基的蛋白质亲缘关系更远，这表明TTG1在向下游转录因子的信号转导中起作用。1.5kb的TTG1转录本存在于拟南芥的所有主要器官中。对六个突变等位基因的序列分析确定了导致TTG1蛋白截短或单个氨基酸变化的碱基变化。
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