Fiermonte G, Pierelli F, Pauri F, Cosentino F I, Soccorsi R, Giacomini P
Istituto di Clinica delle Malattie Nervose e Mentali, Università degli Studi di Roma, La Sapienza, Italy.
Acta Neurol Scand. 1995 Aug;92(2):166-9. doi: 10.1111/j.1600-0404.1995.tb01033.x.
We studied by means of Transcranial Doppler (TCD) recordings the CO2 cerebrovascular reactivity in migraine patients during the headache-free period.
MATERIAL & METHODS: In three groups of subjects (15 controls, 15 suffering from migraine with aura and 15 from migraine without aura) the middle cerebral artery (MCA) mean flow velocity (MFV) was recorded under basal condition and hypocapnia induced by hyperventilation. Relative MFV, PI (Pulsatility Index) changes and Reactivity Index (RI) were calculated.
Reactivity Index values were: 0.019 +/- 0.007 (mean +/- SD) in control subjects: 0.029 +/- 0.008 in migraine with aura; 0.022 +/- 0.008 in migraine without aura. Statistical analysis showed a significantly (P < 0.05) increased RI in migraine with aura group.
Cerebrosvascular CO2 reactivity is increased during the interictal period in migraine with aura patients.
我们通过经颅多普勒（TCD）记录研究了偏头痛患者在无头痛期的二氧化碳脑血管反应性。
在三组受试者（15名对照者、15名有先兆偏头痛患者和15名无先兆偏头痛患者）中，记录了基础状态下以及过度通气诱发低碳酸血症时的大脑中动脉（MCA）平均血流速度（MFV）。计算了相对MFV、搏动指数（PI）变化和反应性指数（RI）。
反应性指数值分别为：对照者0.019±0.007（平均值±标准差）；有先兆偏头痛患者0.029±0.008；无先兆偏头痛患者0.022±0.008。统计分析显示，有先兆偏头痛组的RI显著升高（P<0.05）。
有先兆偏头痛患者在发作间期脑血管二氧化碳反应性增加。
