de Groot M, Jacobson A M, Samson J A, Welch G
Mental Health Unit, Joslin Diabetes Center, McLean Hospital, Boston, Massachusetts, USA.
J Psychosom Res. 1999 May;46(5):425-35. doi: 10.1016/s0022-3999(99)00014-8.
The current study evaluated the association of glycemic control and major depression in 33 type 1 and 39 type 2 diabetes mellitus patients. Type 1 patients with a lifetime history of major depression showed significantly worse glycemic control than patients without a history of psychiatric illness (t = 2.09; df = 31, p < 0.05). Type 2 diabetes patients with a lifetime history of major depression did not have significantly worse control than those with no history of psychiatric illness. Findings from this study indicate different relationships between lifetime major depression and glycemic control for patients with type 1 and type 2 diabetes. Treatment implications for glycemic control in type 1 and type 2 diabetes patients are discussed.
本研究评估了33例1型糖尿病患者和39例2型糖尿病患者的血糖控制与重度抑郁症之间的关联。有重度抑郁症终生病史的1型糖尿病患者的血糖控制明显比无精神疾病史的患者差（t = 2.09；自由度 = 31，p < 0.05）。有重度抑郁症终生病史的2型糖尿病患者的血糖控制并不比无精神疾病史的患者明显更差。本研究结果表明，1型和2型糖尿病患者的终生重度抑郁症与血糖控制之间存在不同的关系。文中还讨论了1型和2型糖尿病患者血糖控制的治疗意义。
