el-Sayed M S, Eastland P, Lin X, Rattu A M
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK.
J Sports Sci. 1999 Jun;17(6):513-20. doi: 10.1080/026404199365821.
The effect of alcohol ingestion before exercise on blood haemostasis is not known. The present study examined the effects of moderate alcohol ingestion on blood haemostatic variables at rest and in response to exercise. Eleven normal healthy individuals randomly performed two tests separated by 7 days. A moderate dose of ethanol (0.5 g.kg-1) was administered before one test, whereas an equal volume of an alcohol-free drink was administered before the other. Forty-five minutes after the ingestion of either drink, the participants cycled at 65% VO2max for 30 min followed by a 5-min all-out performance. Venous blood samples were obtained before and 45 min after the ingestion of both drinks, and also immediately after exercise. Exercise induced a significant increase in tissue-type plasminogen activator activity and antigen, and factor VIII procoagulant activity. The post-exercise data also showed a significant decrease in plasminogen activator inhibitor activity and soluble fibrin, with a significant shortening in prothrombin time and activated partial thromboplastin time, but not thrombin time. No significant changes were observed in antithrombin III. Although no significant differences were found between trials in the haemostatic and fibrinolytic variables at rest, a significant decrease in fibrinogen concentration was observed after exercise in the alcohol trial. This suggests that ingesting a moderate dose of alcohol does not alter blood coagulation and fibrinolysis at rest. Apart from fibrinogen concentration, which was significantly decreased after exercise in the alcohol trial, most of the haemostatic and fibrinolytic variables were not affected by alcohol. The mechanism responsible for the decrease in fibrinogen following exercise in the alcohol trial remains unknown, but might be related to inhibition of fibrinogen synthesis by the liver or an enhanced rate of its catabolism.
运动前摄入酒精对血液止血的影响尚不清楚。本研究检测了适度摄入酒精对静息及运动状态下血液止血变量的影响。11名正常健康个体随机进行两项测试，间隔7天。在其中一项测试前给予中等剂量的乙醇（0.5 g·kg-1），而在另一项测试前给予等量的无酒精饮料。摄入任一饮料45分钟后，参与者以65%最大摄氧量进行30分钟的骑行，随后进行5分钟的全力运动。在摄入两种饮料前、摄入后45分钟以及运动后即刻采集静脉血样本。运动导致组织型纤溶酶原激活物活性和抗原以及凝血因子VIII促凝活性显著增加。运动后的数据还显示纤溶酶原激活物抑制剂活性和可溶性纤维蛋白显著降低，凝血酶原时间和活化部分凝血活酶时间显著缩短，但凝血酶时间未缩短。抗凝血酶III未观察到显著变化。尽管在静息状态下的止血和纤溶变量试验之间未发现显著差异，但在酒精试验中运动后观察到纤维蛋白原浓度显著降低。这表明摄入中等剂量的酒精不会改变静息状态下的血液凝固和纤维蛋白溶解。除了酒精试验中运动后纤维蛋白原浓度显著降低外，大多数止血和纤溶变量不受酒精影响。酒精试验中运动后纤维蛋白原降低的机制尚不清楚，但可能与肝脏对纤维蛋白原合成的抑制或其分解代谢速率的提高有关。
