Yanai H, Murakami T, Yoshiyama H, Takeuchi H, Nishikawa J, Nakamura H, Okita K, Miura O, Shimizu N, Takada K
First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan.
J Clin Gastroenterol. 1999 Jul;29(1):39-43. doi: 10.1097/00004836-199907000-00010.
Although Epstein-Barr virus (EBV) has been reported to be present in some 7% of gastric carcinomas, the nature of the background gastric mucosa of carcinoma has not been elucidated. The authors evaluated the degree of gastritis in the background gastric mucosa of EBV-associated gastric carcinoma. EBV was detected using in situ hybridization for EBV-encoded small ribonucleic acid 1 (EBER-1) in carcinoma cells. The authors compared gastritis in surgically resected stomachs with 8 EBER-1-positive and 16 EBER-1-negative gastric carcinomas of a similar histologic type using histologic variables of the Updated Sydney System. All eight lesions of EBER-1-positive gastric carcinomas had intestinal metaplasia in the background. Mild to moderate glandular atrophy was common in both groups. Many of the tested lesions, 87.5% of EBER-1-positive and 62.5% of EBER-1-negative lesions, were located near the mucosal atrophic border. The background gastric mucosa for EBV-associated gastric carcinomas is rich in atrophic changes. EBV-associated gastric carcinomas are located near the mucosal atrophic border.
尽管据报道约7%的胃癌中存在爱泼斯坦-巴尔病毒（EBV），但癌旁胃黏膜的本质尚未阐明。作者评估了EBV相关胃癌旁胃黏膜的胃炎程度。通过对癌细胞中EBV编码的小核糖核酸1（EBER-1）进行原位杂交检测EBV。作者使用更新后的悉尼系统的组织学变量，比较了8例EBER-1阳性和16例EBER-1阴性、组织学类型相似的手术切除胃标本中的胃炎情况。所有8例EBER-1阳性胃癌病变的背景均有肠化生。两组中轻度至中度腺体萎缩均较为常见。许多检测病变，EBER-1阳性病变的87.5%和EBER-1阴性病变的62.5%，位于黏膜萎缩边界附近。EBV相关胃癌的背景胃黏膜富含萎缩性改变。EBV相关胃癌位于黏膜萎缩边界附近。
