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胆囊癌合并胃出口梗阻

Gastric outlet obstruction in carcinoma gall bladder.

作者信息

Chaudhary A, Dhar P, Sachdev A, Agarwal A

机构信息

Department of Gastrointestinal Surgery, Govind Ballabh Pant Hospital, New Delhi.

出版信息

Indian J Gastroenterol. 1999 Jul-Sep;18(3):101-3.

Abstract

BACKGROUND

Gastric outlet obstruction is occasionally reported to occur in advanced gall bladder malignancy and may require palliative surgery. A review of 39 patients who required gastroenterostomy for symptomatic or incipient gastric outlet obstruction in carcinoma gall bladder is presented.

METHODS

This retrospective review included 24 women and 15 men over nine years who underwent gastrojejunostomy for locally advanced neoplasms of the gall bladder.

RESULTS

Twenty two patients with carcinoma gall bladder had symptomatic gastric outlet obstruction whereas in 17 patients gastrojejunostomy had been performed for intraoperatively assessed impending obstruction. Thirty-four patients had concomitant jaundice. In most cases, there was obstruction of the first two parts of the duodenum, mostly by direct tumoral infiltration (64%). All patients underwent anterior gastrojejunostomy, with billoenteric bypass in 15 patients. There were two postoperative deaths. Eight patients developed postoperative delayed gastric emptying; all settled on conservative management, though two patients had recurrent refractory vomiting. Thirty patients had no vomiting till a follow up ranging from 36 days to 11 months.

CONCLUSIONS

Gastric outlet obstruction may frequently complicate gall bladder cancer and a satisfactory palliation can be achieved in most patients by gastrojejunostomy.

摘要

背景

胃出口梗阻偶尔报道发生于晚期胆囊恶性肿瘤,可能需要姑息性手术。本文回顾了39例因有症状的或早期胃出口梗阻而行胃肠造口术的胆囊癌患者。

方法

这项回顾性研究纳入了9年间24名女性和15名男性患者,他们因胆囊局部晚期肿瘤接受了胃空肠吻合术。

结果

22例胆囊癌患者有症状性胃出口梗阻,而17例患者因术中评估有即将发生梗阻的情况而行胃空肠吻合术。34例患者伴有黄疸。在大多数情况下,十二指肠的前两部分发生梗阻,主要是由于肿瘤直接浸润(64%)。所有患者均接受了前侧胃空肠吻合术,15例患者进行了胆肠旁路手术。有2例术后死亡。8例患者出现术后胃排空延迟;所有患者经保守治疗后病情均得到缓解,不过有2例患者反复出现难治性呕吐。30例患者直至随访36天至11个月期间均未出现呕吐。

结论

胃出口梗阻可能常使胆囊癌病情复杂化,大多数患者通过胃空肠吻合术可获得满意的姑息治疗效果。

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