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[嗜酸性粒细胞性肺病]

[The eosinophilic lung].

作者信息

Miltgen J, Nguyen Hy Thuy G, Gueguen E, Cuguilliere A, Bonnet D

机构信息

Travail du Service de Pneumologie, Hôpital d'Instruction des Armées Laveran, Marseille, France.

出版信息

Med Trop (Mars). 1998;58(4 Suppl):447-53.

Abstract

Eosinophilic lung disease comprises a diverse group of disorders characterized by eosinophilic pulmonary infiltration in association with other inflammatory cells. In patients with respiratory symptoms, usually associated with radiographically documented infiltrates, blood eosinophilia is a helpful but inconsistent diagnostic finding. Currently diagnosis is confirmed more often by bronchoalveolar lavage than by lung biopsy. Possible etiologies include parasites, mycotic agents, drugs, and angeitis. Remaining cases are classified as idiopathic eosinophilic lung disease including Carrington's disease, idiopathic hypereosinophilic syndrome, acute eosinophilic pneumonia, and Loeffler's syndrome. Mild eosinophilia is also a possible finding of bronchoalveolar lavage in several other disorders but the role of eosinophils is less important. The prognosis and treatment of eosinophilic lung disease varies depending on etiology. Corticosteroids are frequently used but treatment modalities also depend on etiology.

摘要

嗜酸性粒细胞性肺病是一组多样的疾病,其特征为嗜酸性粒细胞在肺部浸润,并伴有其他炎症细胞。对于有呼吸道症状且通常伴有影像学证实的浸润影的患者,血液嗜酸性粒细胞增多是一项有用但并不一致的诊断发现。目前,通过支气管肺泡灌洗确诊的情况比肺活检更为常见。可能的病因包括寄生虫、真菌、药物和血管炎。其余病例归类为特发性嗜酸性粒细胞性肺病,包括卡林顿病、特发性高嗜酸性粒细胞综合征、急性嗜酸性粒细胞性肺炎和吕弗勒综合征。轻度嗜酸性粒细胞增多在其他几种疾病的支气管肺泡灌洗中也可能出现,但嗜酸性粒细胞的作用不太重要。嗜酸性粒细胞性肺病的预后和治疗因病因不同而异。经常使用皮质类固醇,但治疗方式也取决于病因。

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