宫颈上皮内瘤变与男性人乳头瘤病毒感染之间的相关性：一项纵向研究。

Correlation between cervical intraepithelial neoplasia and human papillomavirus male infections: a longitudinal study.

作者信息

Frega A, Stentella P, Villani C, Di Ruzza D, Marcomin G L, Rota F, Boninfante M, Pachì A

机构信息

II Department of Obstetrics and Gynecology, University La Sapienza, Rome, Italy.

出版信息

Eur J Gynaecol Oncol. 1999;20(3):228-30.

PMID:10410894

Abstract

BACKGROUND

Genital HPV infection is one of the most common sexually-transmitted diseases. The aim of the study was to evaluate the correlation between HPV-associated lesions in male partners of women affected by CIN.

METHODS

210 male partners of women affected by CIN were examined in a long-term follow-up (from 5 to 13 years). The diagnosis in females was performed by cytology, colposcopy and histology. Male partners were submitted to clinical examination, peniscopy and biopsy.

RESULTS

111/210 (53%) females had CIN I, 53/210 (25%) and 46/210 (22%) had CIN III. Subclinical lesions were associated with 18%, 28% and 24% of male partners of women with CIN I, CIN II and CIN III, respectively. Clinical lesions were observed in 7% and 10% of sexual partners of women with CIN I and CIN II, respectively. Mixed lesions affected only 3% of sexual partners of women with CIN I.

CONCLUSIONS

Our data show that the transmissibility of HPV infection to the male partners of women affected by CIN was easier when there was a lower grade of CIN. In fact, male partners of women with CIN III had a lower percentage (26%) of clinical or subclinical HPV skin lesions.

摘要

背景

生殖器HPV感染是最常见的性传播疾病之一。本研究的目的是评估受CIN影响女性的男性伴侣中HPV相关病变之间的相关性。

方法

对210名受CIN影响女性的男性伴侣进行了长期随访（5至13年）。女性的诊断通过细胞学、阴道镜检查和组织学进行。男性伴侣接受了临床检查、阴茎镜检查和活检。

结果

111/210（53%）的女性患有CIN I，53/210（25%）和46/210（22%）患有CIN III。亚临床病变分别与CIN I、CIN II和CIN III女性的18%、28%和24%的男性伴侣相关。在CIN I和CIN II女性的性伴侣中，分别有7%和10%观察到临床病变。混合病变仅影响CIN I女性性伴侣的3%。