Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece.
BMC Infect Dis. 2019 Feb 26;19(1):192. doi: 10.1186/s12879-019-3805-x.
Human Papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection. The present systematic review summarizes data regarding the prevalence of HPV and the distribution of subtypes in heterosexual male partners of women, who were diagnosed with any grade of cervical intraepithelial neoplasia (CIN).
We conducted a systematic review of the literature by Medline and Google Scholar databases using the terms "Human Papillomavirus" or "HPV" plus "men" or "male partners" or "women with CIN". We included original published English-language articles published from 1/1/2000 until 1/1/2018 that had screened male partners of women with CIN using HPV DNA testing. We excluded studies that they overlapped with other included studies or were unrelated to the study subject.
We included a total of 12 publications, which reported the prevalence of HPV in free-clinical signs male partners of women with CIN. The largest proportion of the studies were from South America (seven studies), and the rest from Europe. The mean age of participants was 35.18 + - 3.47 years. HPV prevalence ranged from 12.9 to 86%; the total HPV prevalence among the studies was 49.1%, while ten out twelve studies (83.3%) demonstrated prevalence > 20%. Between the studies, the distribution of HPV subtypes varied on the basis of the method used, on the population and on the geographic region. A great variety of subtypes were detected, including 6, 11, 16, 18, 31, 33, 40, 42, 45, 51, 52, 53, 54, 56, 57, 58, 59, 61, 62, 66, 68, 81 and 83. In six studies the HPV 16 was the most frequent, while in two others the HPV 6 and HPV 83.
Until now, there are not precise screening or surveillance guidelines for the management of partners of women with CIN. This population is frequently colonized by various HPV subtypes and therefore need to be screened in an effort to reduce the infection in both sexes. The screening test could include detection/identification of HPV subtypes by a molecular assay, followed by peniscopy only in the positive cases.
人乳头瘤病毒（HPV）感染估计是最常见的性传播感染。本系统综述总结了关于 HPV 流行率以及在被诊断为任何级别宫颈上皮内瘤变（CIN）的女性异性性伴侣中 HPV 亚型分布的数据。
我们通过 Medline 和 Google Scholar 数据库使用“人乳头瘤病毒”或“HPV”加“男性”或“男性伴侣”或“患有 CIN 的女性”等术语进行了系统文献回顾。我们纳入了自 2000 年 1 月 1 日至 2018 年 1 月 1 日发表的、使用 HPV DNA 检测筛查 CIN 女性异性性伴侣的原始英文发表文章。我们排除了与其他纳入研究重叠或与研究主题无关的研究。
我们共纳入 12 项研究，报告了 CIN 女性异性性伴侣中 HPV 的流行率。最大比例的研究来自南美洲（7 项研究），其余来自欧洲。参与者的平均年龄为 35.18±3.47 岁。HPV 流行率范围为 12.9%至 86%；12 项研究中 HPV 的总流行率为 49.1%，其中 10 项（83.3%）研究的流行率>20%。研究之间，HPV 亚型的分布基于所使用的方法、人群和地理区域而有所不同。检测到多种亚型，包括 6、11、16、18、31、33、40、42、45、51、52、53、54、56、57、58、59、61、62、66、68、81 和 83。在 6 项研究中，HPV 16 最为常见，而在另外 2 项研究中 HPV 6 和 HPV 83 最为常见。
到目前为止，针对 CIN 女性伴侣的管理尚无确切的筛查或监测指南。该人群常被多种 HPV 亚型定植，因此需要进行筛查，以减少两性的感染。筛查试验可包括通过分子检测法检测/鉴定 HPV 亚型，仅在阳性病例中进行阴茎检查。
