Bleeker Maaike C G, Hogewoning Cornelis J A, Van Den Brule Adriaan J C, Voorhorst Feja J, Van Andel Rick E, Risse Elle K J, Starink Theo M, Meijer Chris J L M
Department of Pathology, Section Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands.
J Am Acad Dermatol. 2002 Sep;47(3):351-7. doi: 10.1067/mjd.2002.122198.
Genital human papillomavirus infection (HPV) is causally associated with cervical carcinomas and premalignant lesions. Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).
The aim of this study was to identify the presence of penile lesions and HPV in penile scrapings from male sexual partners of women with CIN.
One hundred seventy-five male sexual partners of women with CIN were screened by peniscopy after acetowhite staining and HPV testing on penile scrapings.
Penile lesions were seen in 68% of the male sexual partners. More than one lesion type was diagnosed in 15%. Flat lesions, papular lesions, and condylomata acuminata were seen in 83%, 29%, and 4%, respectively. HPV was detected in 59% of the penile scrapings, containing mainly oncogenic HPV types. When penile lesions were present at peniscopy, 67% of penile scrapings were positive for HPV, whereas 37% were HPV-positive when no lesions were visible.
Penile lesions are frequently found in sexual partners of women with CIN. Most of these lesions are subclinical (ie, only visible after acetowhite staining) and are often associated with the presence of high-risk HPV, indicating that male sexual partners of women with CIN might constitute a reservoir for high-risk HPV.
生殖器人乳头瘤病毒感染（HPV）与宫颈癌及癌前病变存在因果关系。关于宫颈上皮内瘤变（CIN）女性性伴侣中HPV感染率及阴茎病变的信息有限。
本研究旨在确定CIN女性性伴侣阴茎刮片中阴茎病变及HPV的存在情况。
对175例CIN女性的男性性伴侣进行醋酸白染色后阴茎镜检查及阴茎刮片HPV检测。
68%的男性性伴侣存在阴茎病变。15%的患者诊断出不止一种病变类型。扁平病变、丘疹样病变及尖锐湿疣分别占83%、29%和4%。59%的阴茎刮片检测到HPV，主要为致癌性HPV类型。阴茎镜检查发现阴茎病变时，67%的阴茎刮片HPV呈阳性，而无病变可见时37%的刮片HPV呈阳性。
CIN女性性伴侣中常发现阴茎病变。这些病变大多为亚临床病变（即仅在醋酸白染色后可见），且常与高危HPV感染有关，表明CIN女性的男性性伴侣可能是高危HPV的储存宿主。
