Richardson S D, Collette T W, Price P C, Genicola F A, Jenks J W, Thruston A D, Ellington J J
U.S. Environmental Protection Agency, National Exposure Research Laboratory, Athens, Georgia 30605, USA.
J Expo Anal Environ Epidemiol. 1999 May-Jun;9(3):200-16. doi: 10.1038/sj.jea.7500020.
Using a combination of gas chromatography/mass spectrometry (GC/MS) and gas chromatography/infrared spectroscopy (GC/IR) spectroscopic techniques, chemical contaminants and their hydrolysis products were identified in well water sampled in connection with a suspected childhood cancer cluster located in Dover Township, Ocean County, New Jersey. The drinking water contamination resulted from the leaching of industrial waste chemicals from drums that were disposed of at the site known as Reich Farm. Contaminants identified include dinitrile-tetralin compounds, known as 'trimers,' that are by-products of a polymerization process widely used by several polymer manufactures during the 1970s and 1980s (and still used today). Also identified were 'trimer' hydrolysis products, formed by the hydrolysis of their nitrile groups to amides. These industrial contaminants were not present in any of the mass or IR spectral library databases, and their identification required unconventional spectroscopic methods (including high resolution mass spectrometry, chemical ionization mass spectrometry, and IR spectroscopy), along with scientific reasoning and interpretation. It is currently not known whether these chemical contaminants are responsible for the childhood cancers observed in this area.
利用气相色谱/质谱联用（GC/MS）和气相色谱/红外光谱联用（GC/IR）光谱技术，在新泽西州海洋县多佛镇一处疑似儿童癌症聚集区采集的井水样本中，鉴定出了化学污染物及其水解产物。饮用水污染是由于存放在名为赖希农场的场地的桶中工业废化学物质的沥滤所致。鉴定出的污染物包括二腈 - 四氢化萘化合物，即所谓的“三聚体”，它们是20世纪70年代和80年代几家聚合物制造商广泛使用的聚合过程的副产物（如今仍在使用）。还鉴定出了“三聚体”水解产物，它们是由腈基水解为酰胺形成的。这些工业污染物在任何质谱或红外光谱库数据库中均不存在，其鉴定需要非常规光谱方法（包括高分辨率质谱、化学电离质谱和红外光谱），以及科学推理和解释。目前尚不清楚这些化学污染物是否与该地区观察到的儿童癌症有关。
