Richardson C R, Mellonig J T, Brunsvold M A, McDonnell H T, Cochran D L
The University of Texas, Health Science Center at S.A., Department of Periodontics, San Antonio, 78284-7894, USA.
J Clin Periodontol. 1999 Jul;26(7):421-8. doi: 10.1034/j.1600-051x.1999.260702.x.
The purpose of this study was to compare the bovine derived xenograft (BDX) Bio-Oss to demineralized freeze dried bone allograft (DFDBA) in human intrabony defects. 17 healthy patients with no systemic disease with moderate-severe periodontitis (7 males, 10 females; aged 34-67), were treated. Surgically, defects were included only if the intraosseous defect depth was >3.0 mm. Final selection included 30 defects. The sites were randomly assigned treatment with DFDBA or BDX. Soft tissue and osseous defect measurements were taken the day of surgery and 6 months post-operatively at re-entry. Average baseline PD, CAL, and surgical defect depth for the DFDBA group were not statistically different from the BDX group. No adverse healing response occurred. The results showed a statistically significant improvement in PD and AL for both materials at 6 months in 26 defects (4 defects did not respond to therapy). Soft tissue measurements for the DFDBA group included PD reduction of 2.0+/-1.3 mm, and AL gain of 2.6+/-1.6 mm, while the BDX group showed a PD reduction of 3.0+/-1.7 mm, and AL gain of 3.6+/-1.8 mm. Osseous measurements showed bone fill of 2.4 mm (46.8%) for the DFDBA group and 3.0 mm (55.8%) for the BDX group. Defect resolution was 59.4% for the DFDBA group and 77.6% for the BDX group. Statistical analysis revealed there was no statistical difference between the 2 materials in all measurements.
本研究的目的是比较牛源异种骨移植材料（BDX）Bio-Oss与脱矿冻干同种异体骨（DFDBA）在人类骨内缺损中的应用效果。对17例无全身疾病的中重度牙周炎患者（7例男性，10例女性；年龄34 - 67岁）进行了治疗。手术方面，仅当骨内缺损深度>3.0 mm时才纳入缺损病例。最终选定30个缺损部位。这些部位被随机分配接受DFDBA或BDX治疗。在手术当天以及术后6个月再次手术时进行软组织和骨缺损测量。DFDBA组的平均基线牙周袋深度（PD）、临床附着丧失（CAL）和手术缺损深度与BDX组相比无统计学差异。未出现不良愈合反应。结果显示，26个缺损部位在6个月时，两种材料的PD和附着水平（AL）均有统计学意义上的显著改善（4个缺损部位对治疗无反应）。DFDBA组的软组织测量结果包括PD减少2.0±1.3 mm，AL增加2.6±1.6 mm，而BDX组显示PD减少3.0±1.7 mm，AL增加3.6±1.8 mm。骨测量结果显示，DFDBA组骨填充为2.4 mm（46.8%），BDX组为3.0 mm（55.8%）。DFDBA组的缺损修复率为59.4%，BDX组为77.6%。统计分析表明，两种材料在所有测量指标上均无统计学差异。
