Pan P H, Finnegan M B, Sturdivant L, Barnett M L
The Warner-Lambert Company, Morris Plains, NJ 07950, USA.
J Clin Periodontol. 1999 Jul;26(7):474-6. doi: 10.1034/j.1600-051x.1999.260710.x.
Although laboratory studies are not necessarily predictive of clinical activity; they can help to elucidate mechanisms underlying clinical activity when the latter has been established. In a recent clinical study, an essential oil mouthrinse (Listerine Antiseptic) was shown to be significantly more effective than an amine fluoride/stannous fluoride mouthrinse (Meridol) in inhibiting supragingival plaque formation. This paper reports the results of laboratory studies comparing the antimicrobial effectiveness of these 2 mouthrinses using a kill kinetics assay and a plaque biofilm kill assay. In both assays, the essential oil mouthrinse was considerably more effective than the amine fluoride/stannous fluoride mouthrinse. These findings are consistent with the results of the clinical trial and may help to explain the observed differences in clinical activity.
虽然实验室研究不一定能预测临床活性，但当临床活性确定后，它们有助于阐明其潜在机制。在最近的一项临床研究中，一种精油漱口水（李施德林抗菌漱口水）在抑制龈上菌斑形成方面比氟化胺/氟化亚锡漱口水（美利道）显著更有效。本文报告了使用杀菌动力学测定法和菌斑生物膜杀灭测定法比较这两种漱口水抗菌效果的实验室研究结果。在这两种测定法中，精油漱口水比氟化胺/氟化亚锡漱口水有效得多。这些发现与临床试验结果一致，可能有助于解释观察到的临床活性差异。
