Atazhanova Gayane A, Levaya Yana K, Badekova Karakoz Zh, Ishmuratova Margarita Yu, Smagulov Marlen K, Ospanova Zhanna O, Smagulova Elina M
School of Pharmacy, Karaganda Medical University, Gogol Street, 40, Karaganda 100012, Kazakhstan.
Research Park of Biotechnology and Eco-Monitoring, Karaganda Buketov University, Universitetskaya Street, 28, Karaganda 100026, Kazakhstan.
Pharmaceuticals (Basel). 2024 Nov 29;17(12):1613. doi: 10.3390/ph17121613.
This review is devoted to a systematic analysis of studies aimed at investigating plant extracts, essential oils and phytochemical compounds capable of inhibiting biofilm formation. This paper investigates the effect of extracts, essential oils and individual plant compounds on inhibiting the biofilm formation of , one of the major pathogens responsible for the development of dental caries. Using cultural microbiology and molecular biology techniques, the authors describe the mechanisms by which plant samples reduce adhesion and growth. The results show that several plant components have antibacterial properties, contributing to the reduction of colony numbers and inhibiting the synthesis of extract-exopolysaccharide matrices required for biofilm formation. This work highlights the potential of botanicals in inhibiting biofilm formation, which can be applied as natural antimicrobial agents in the prevention and treatment of dental diseases. Views on the use of these plant extracts and their components in dental preparations such as toothpastes, rinses and gels aimed at preventing dental caries are evaluated. The review shows the relevance of the research to optimizing the use of plant extracts, essential oils, individual compounds and their active actions in the control of biofilms.
本综述致力于对旨在研究能够抑制生物膜形成的植物提取物、精油和植物化学化合物的研究进行系统分析。本文研究了提取物、精油和单一植物化合物对变形链球菌生物膜形成的抑制作用,变形链球菌是导致龋齿发生的主要病原体之一。作者运用培养微生物学和分子生物学技术,描述了植物样本减少变形链球菌黏附和生长的机制。结果表明,几种植物成分具有抗菌特性,有助于减少变形链球菌菌落数量,并抑制生物膜形成所需的胞外多糖基质的合成。这项工作突出了植物提取物在抑制变形链球菌生物膜形成方面的潜力,可作为天然抗菌剂应用于预防和治疗牙科疾病。文中评估了在旨在预防龋齿的牙膏、漱口水和凝胶等牙科制剂中使用这些植物提取物及其成分的观点。该综述表明了该研究对于优化植物提取物、精油、单一化合物及其在控制变形链球菌生物膜方面的活性作用的相关性。