Thonneau P, Abell A, Larsen S B, Bonde J P, Joffe M, Clavert A, Ducot B, Multigner L, Danscher G
Institut National de la Santé et de la Recherche Médicale, Unité 292, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
Am J Epidemiol. 1999 Jul 15;150(2):157-63. doi: 10.1093/oxfordjournals.aje.a009975.
The aim of this study was to determine whether there was a relation between male exposure to pesticides and the amount of time needed to conceive (time to pregnancy) for farmers and agricultural workers in France and Denmark. The authors used retrospective studies to compare the time to pregnancy of couples in which the man was exposed to pesticides during the year before the birth of their youngest child with that of couples in which the man was not exposed. In 1995 and 1996, the authors studied 362 French rural workers (142 exposed to pesticides and 220 not exposed), 449 Danish farmers (326 conventional farmers exposed to pesticides and 123 nonexposed organic farmers), and 121 Danish greenhouse workers exposed to pesticides. The fecundability ratio for exposure to pesticides (Cox model, before and after adjustment for confounding factors) did not differ from 1 in any of the three populations. In France, the adjusted fecundability ratio was 1.17 (95% confidence interval (CI) 0.89-1.55) for exposed and nonexposed agricultural workers. In Denmark, it was 1.09 (95% CI 0.82-1.43) for exposed and nonexposed farmers and 0.83 (95% CI 0.69-1.18) for greenhouse workers and nonexposed farmers. Thus, this study found no relation between fertility (time to pregnancy) and male exposure to pesticides.
本研究的目的是确定在法国和丹麦，男性农民和农业工人接触农药与受孕所需时间（怀孕时间）之间是否存在关联。作者采用回顾性研究方法，比较了在其最小孩子出生前一年男方接触农药的夫妇与男方未接触农药的夫妇的怀孕时间。1995年和1996年，作者研究了362名法国农村工人（142名接触农药，220名未接触）、449名丹麦农民（326名接触农药的传统农民和123名未接触农药的有机农民）以及121名接触农药的丹麦温室工人。在这三个人群中，任何一个人群接触农药的生育力比（Cox模型，在对混杂因素进行调整前后）均与1无差异。在法国，接触和未接触农药的农业工人调整后的生育力比为1.17（95%置信区间（CI）0.89 - 1.55）。在丹麦，接触和未接触农药的农民调整后的生育力比为1.09（95%CI 0.82 - 1.43），温室工人与未接触农药的农民相比调整后的生育力比为0.83（95%CI 0.69 - 1.18）。因此，本研究未发现生育力（怀孕时间）与男性接触农药之间存在关联。
