Harley Kim G, Marks Amy R, Bradman Asa, Barr Dana B, Eskenazi Brenda
Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, Calif 94704-7380, USA.
J Occup Environ Med. 2008 Dec;50(12):1335-42. doi: 10.1097/JOM.0b013e31818f684d.
This study examined whether exposure to pesticides, including dichlorodiphenyltrichloroethane (DDT), was associated with longer time to pregnancy (TTP).
Pregnant women (N = 402) living in a migrant farmworker community were asked how many months they took to conceive. Women reported their and their partners' occupational and home pesticide exposure preceding conception. In a subset (N = 289), levels of DDT and dichlorodiphenyldichloroethylene (DDE), were measured in maternal serum.
No associations were seen with p, p'-DDT, o, p'-DDT, or p, p'-DDE. Maternal occupational pesticide exposure (fecundability odds ratios [fOR] = 0.8, 95% CI: 0.6 to 1.0), home pesticide use (fOR = 0.6, 95% CI: 0.4 to 0.9), and residence within 200 ft of an agricultural field (fOR = 0.7, 95% CI: 0.5 to 1.0) were associated with reduced fecundability (ie, longer TTP).
Longer TTP was seen among women, but not men, reporting exposure to agricultural and home pesticides.
本研究调查了包括二氯二苯三氯乙烷（滴滴涕）在内的农药暴露是否与受孕时间延长有关。
对居住在流动农场工人社区的孕妇（N = 402）询问她们受孕花费了几个月时间。这些女性报告了她们及其伴侣在受孕前的职业和家庭农药暴露情况。在一个亚组（N = 289）中，检测了孕妇血清中滴滴涕和二氯二苯二氯乙烯（DDE）的水平。
未发现与p,p'-滴滴涕、o,p'-滴滴涕或p,p'-DDE有关联。孕妇职业性农药暴露（受孕几率比[fOR] = 0.8，95%置信区间：0.6至1.0）、家庭使用农药（fOR = 0.6，95%置信区间：0.4至0.9）以及居住在距农田200英尺范围内（fOR = 0.7，95%置信区间：0.5至1.0）与受孕几率降低（即受孕时间延长）有关。
报告有农业和家庭农药暴露的女性受孕时间延长，但男性未出现这种情况。
