Krogstad P, Uittenbogaart C H, Dickover R, Bryson Y J, Plaeger S, Garfinkel A
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California 90095-5217, USA.
Clin Immunol. 1999 Jul;92(1):25-33. doi: 10.1006/clim.1999.4728.
Acute HIV infection is characterized by the appearance of high concentrations of virus in the peripheral blood. In adults, this high-level viremia spontaneously abates after several weeks. In contrast, after perinatal infection of infants, blood virus levels remain high for many months, during which the concentration of circulating CD4+ lymphocytes remains well above normal values for adults. Here we suggest an explanation for these differences, based on developmental factors including somatic growth and immunological ontogeny. Flow cytometric analysis revealed that at birth the thymus contains elevated levels of mature T lymphocytes, compared to the thymus after 3 months of age. A mathematical model is proposed incorporating immunological and virological data from longitudinally evaluated infants who acquired infection at the time of birth. This model explains the pattern of high-level viremia in infants as resulting from the replication of HIV within the progressively expanding lymphoid cell mass.
急性HIV感染的特征是外周血中出现高浓度病毒。在成人中，这种高水平病毒血症在数周后会自发消退。相比之下，婴儿围产期感染后，血液病毒水平会在许多个月内保持高位，在此期间，循环CD4+淋巴细胞的浓度仍远高于成人的正常值。在此，我们基于包括体细胞生长和免疫个体发生在内的发育因素，对这些差异提出一种解释。流式细胞术分析显示，与3个月大后的胸腺相比，出生时胸腺中成熟T淋巴细胞水平升高。我们提出了一个数学模型，该模型纳入了对出生时感染的婴儿进行纵向评估得到的免疫学和病毒学数据。该模型解释了婴儿高水平病毒血症的模式是由HIV在逐渐扩大的淋巴细胞群体中复制所致。
